Endocrine Abstracts

Introduction: Sheehan’s syndrome is a rare postpartum complication. Recurrent hypoglycaemia,though described is a rare complication of Sheehan syndrome. Here we report a case of Sheehan syndrome which presented with hypoglycemic coma.Case Presentation: We report the case of a 47-year-old woman who presented to the medical emergency unit with coma. There was no history of chest pain, fever, headache, vomiting, trauma, or seizures. She had no history ...

Introduction: Ganglioneuroma is a rare benign tumour arising from neural crest sympathogonia. It is usually asymptomatic and non functional. An association between ganglioeneuroma and genetic or autoimmune diseases such as Addison’s disease or Mediterranean fever has never been described.Case description: We report the case of a 24-year-old woman presenting with paroxysmal abdominal pain with loss of weight and no fever. Physical examination along w...

Introduction: The otorhinolaryngologist can be confronted to multiple surprises after a thyroid surgeryCase description: We report the case of a 48 year-old woman admitted with post operative hypocalcaemia (after thyroidectomy?). The patient has a history of hypothyroidism since 5 years. She then presented a cervical swelling. The ultra-sound confirmed the presence of a suspicious thyroid nodule measuring 4 cm. A thyroidectomy was then conducted. Post op...

Introduction: Majority of patients with neuroendocrine tumors (NET) harbor hepatic metastases at presentation, posing therapeutic challenge. Multiple liver-directed treatment modalities have been employed with variable success. Herein is presented successful outcome in a patient whose recurrent metastatic liver metastases from NET was managed using multidisciplinary approach.Case report: We present long-term18-years course of a patient with liver metasta...

Background: Early diagnosis of girls with turner syndrome (TS) is essential to provide timely intervention and support. The screening guidelines for TS suggest karyotype evaluation in patients presenting with short stature, webbed neck, lymphoedema, coarctation of aorta or >two dysmorphic features (nail dysplasia, high arched palate, short fourth metacarpal or strabismus).Objectives: The aim of the study was to determine the age and clinical features...

Introduction: Congenital hyperinsulinism (CHI) results from unregulated insulin secretion from pancreatic β-cells, which leads to persistent hypoglycaemia. Mutations in nine different genes are reported and phenotypic variability exists both within and between the genetic subgroups. Variable penetrance has been described in some families with the same mutation; for example HNF4A mutations cause neonatal hypoglycaemia and/or maturity onset diabetes of the young (M...

Effective treatment of differentiated thyroid cancer relies on a multifaceted approach often including administration of 131I to ablate residual cancer cells post-surgery. The success of this treatment hinges upon adequate uptake of iodide by malignant thyroid follicular cells. In a subset of patients, dedifferentiation of the carcinoma can result in aberrant expression and trafficking of the iodide transport protein, the sodium iodide symporter (NIS), resulting in ...

Introduction: Diabetes Insipidus (DI) is the inability of the kidneys to concentrate urine. This is due to decreased production of Anti-diuretic Hormone (ADH) from the posterior pituitary gland (cranial DI) or decreased tubular sensitivity to ADH (nephrogenic DI) or a mixed picture.Case: A 53-year-old male presented with several-months history of polyuria and polydipsia. He had constant thirst and had to void urine four times at night. He did not have di...

Resistin promotes both inflammation and insulin resistance associated with energy homeostasis impairment. Resistin is secreted by adipose tissue and macrophages, but its mechanism of action remained unknown because its receptor was not characterised. Recently, we have shown that central resistin acts by way of hypothalamic TLR4 receptors promoting overall inflammation and insulin resistance. Here, we aim to block resistin action in HFD mice that are prone to obesity and inflam...

Introduction: SDH genes mutations are associated with hereditary phaeochromocytoma and paraganglioma syndromes. We describe the case of a patient with SDHC related familial paraganglioma and pituitary adenoma.Case: A 65-year old man consulted for an incidentally discovered 7 cm abdominal mass on CT-scan, lateral to the right kidney, invading inferior vena cava, associated to a retroperitoneal adenomegaly and a lesion on the body of L2 vertebra with spina...